25-hydroxyvitamin D, vitamin D receptor gene polymorphisms, and severity of Parkinson's disease.
Identifieur interne : 000F26 ( Main/Exploration ); précédent : 000F25; suivant : 000F2725-hydroxyvitamin D, vitamin D receptor gene polymorphisms, and severity of Parkinson's disease.
Auteurs : Masahiko Suzuki [Japon] ; Masayuki Yoshioka ; Masaya Hashimoto ; Maiko Murakami ; Keiichi Kawasaki ; Miki Noya ; Daisuke Takahashi ; Mitsuyoshi UrashimaSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2012.
English descriptors
- KwdEn :
- Aged, Aged, 80 and over, Cohort Studies, Cross-Sectional Studies, Female, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Parkinson Disease (blood), Parkinson Disease (genetics), Polymorphism, Genetic, Receptors, Calcitriol (genetics), Severity of Illness Index, Vitamin D (analogs & derivatives), Vitamin D (blood), Vitamin D (genetics).
- MESH :
- chemical , analogs & derivatives : Vitamin D.
- chemical , blood : Vitamin D.
- chemical , genetics : Receptors, Calcitriol, Vitamin D.
- blood : Parkinson Disease.
- genetics : Parkinson Disease.
- Aged, Aged, 80 and over, Cohort Studies, Cross-Sectional Studies, Female, Genetic Predisposition to Disease, Humans, Male, Middle Aged, Polymorphism, Genetic, Severity of Illness Index.
Abstract
We aimed to examine associations among serum 25-hydroxyvitamin D levels, 1,25-dihyroxyvitamin D levels, vitamin D receptor polymorphisms, vitamin D binding protein gene polymorphisms, and the severity of Parkinson's disease. In 137 patients, the severity of Parkinson's disease was evaluated using Hoehn & Yahr stage and Unified Parkinson's Disease Rating Stage by neurologists and compared with 25-hydroxyvitamin D, 1,25-hydroxyvitamin D, vitamin D receptor polymorphisms, ie, FokI (rs10735810), BsmI (rs1544410), Cdx2 (rs11568820), ApaI (rs7976091), and TaqI (rs731236), and vitamin D binding protein gene polymorphisms GC1 (rs7041)/GC2 (rs4588) in a cross-sectional study. Mean ± standard deviation levels of 25-hydroxyvitamin D were 21.1 ± 9.0 ng/mL. Levels were deficient (<20 ng/mL) in 49% of patients. In contrast, 1,25-hydroxyvitamin D levels were considered normal in all patients. Higher circulating 25-hydroxyvitamin D levels were significantly associated with milder Parkinson's disease evaluated by Hoehn & Yahr stage (P = .002) and total Unified Parkinson's Disease Rating Stage (P = .004) even after multivariate adjustment for 8 covariates, including disease duration. However, significant associations were not observed in 1,25-hydroxyvitamin D levels. Under multivariate analysis with 25-hydroxyvitamin D as well as other 8 covariates including disease duration, carriers of vitamin D receptor FokICC genotype had a milder form of Parkinson's disease: odds ratio, 0.32; 95% confidence interval, 0.16 to 0.66, P = 0.002. These results suggest that higher 25-hydroxyvitamin D levels and the vitamin D receptor FokICC genotype may be independently associated with milder forms of Parkinson's disease. However, significant associations were not observed in 1,25-hydroxyvitamin D levels.
DOI: 10.1002/mds.24016
PubMed: 22213340
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: 000F11
- to stream PubMed, to step Curation: 000F11
- to stream PubMed, to step Checkpoint: 000F85
- to stream Ncbi, to step Merge: 003519
- to stream Ncbi, to step Curation: 003519
- to stream Ncbi, to step Checkpoint: 003519
- to stream Main, to step Merge: 000F77
- to stream Main, to step Curation: 000F26
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">25-hydroxyvitamin D, vitamin D receptor gene polymorphisms, and severity of Parkinson's disease.</title><author><name sortKey="Suzuki, Masahiko" sort="Suzuki, Masahiko" uniqKey="Suzuki M" first="Masahiko" last="Suzuki">Masahiko Suzuki</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Jikei University School of Medicine, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Jikei University School of Medicine, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Yoshioka, Masayuki" sort="Yoshioka, Masayuki" uniqKey="Yoshioka M" first="Masayuki" last="Yoshioka">Masayuki Yoshioka</name></author><author><name sortKey="Hashimoto, Masaya" sort="Hashimoto, Masaya" uniqKey="Hashimoto M" first="Masaya" last="Hashimoto">Masaya Hashimoto</name></author><author><name sortKey="Murakami, Maiko" sort="Murakami, Maiko" uniqKey="Murakami M" first="Maiko" last="Murakami">Maiko Murakami</name></author><author><name sortKey="Kawasaki, Keiichi" sort="Kawasaki, Keiichi" uniqKey="Kawasaki K" first="Keiichi" last="Kawasaki">Keiichi Kawasaki</name></author><author><name sortKey="Noya, Miki" sort="Noya, Miki" uniqKey="Noya M" first="Miki" last="Noya">Miki Noya</name></author><author><name sortKey="Takahashi, Daisuke" sort="Takahashi, Daisuke" uniqKey="Takahashi D" first="Daisuke" last="Takahashi">Daisuke Takahashi</name></author><author><name sortKey="Urashima, Mitsuyoshi" sort="Urashima, Mitsuyoshi" uniqKey="Urashima M" first="Mitsuyoshi" last="Urashima">Mitsuyoshi Urashima</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="doi">10.1002/mds.24016</idno><idno type="RBID">pubmed:22213340</idno><idno type="pmid">22213340</idno><idno type="wicri:Area/PubMed/Corpus">000F11</idno><idno type="wicri:Area/PubMed/Curation">000F11</idno><idno type="wicri:Area/PubMed/Checkpoint">000F85</idno><idno type="wicri:Area/Ncbi/Merge">003519</idno><idno type="wicri:Area/Ncbi/Curation">003519</idno><idno type="wicri:Area/Ncbi/Checkpoint">003519</idno><idno type="wicri:Area/Main/Merge">000F77</idno><idno type="wicri:Area/Main/Curation">000F26</idno><idno type="wicri:Area/Main/Exploration">000F26</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">25-hydroxyvitamin D, vitamin D receptor gene polymorphisms, and severity of Parkinson's disease.</title><author><name sortKey="Suzuki, Masahiko" sort="Suzuki, Masahiko" uniqKey="Suzuki M" first="Masahiko" last="Suzuki">Masahiko Suzuki</name><affiliation wicri:level="3"><nlm:affiliation>Department of Neurology, Jikei University School of Medicine, Tokyo, Japan.</nlm:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Neurology, Jikei University School of Medicine, Tokyo</wicri:regionArea><placeName><settlement type="city">Tokyo</settlement></placeName></affiliation></author><author><name sortKey="Yoshioka, Masayuki" sort="Yoshioka, Masayuki" uniqKey="Yoshioka M" first="Masayuki" last="Yoshioka">Masayuki Yoshioka</name></author><author><name sortKey="Hashimoto, Masaya" sort="Hashimoto, Masaya" uniqKey="Hashimoto M" first="Masaya" last="Hashimoto">Masaya Hashimoto</name></author><author><name sortKey="Murakami, Maiko" sort="Murakami, Maiko" uniqKey="Murakami M" first="Maiko" last="Murakami">Maiko Murakami</name></author><author><name sortKey="Kawasaki, Keiichi" sort="Kawasaki, Keiichi" uniqKey="Kawasaki K" first="Keiichi" last="Kawasaki">Keiichi Kawasaki</name></author><author><name sortKey="Noya, Miki" sort="Noya, Miki" uniqKey="Noya M" first="Miki" last="Noya">Miki Noya</name></author><author><name sortKey="Takahashi, Daisuke" sort="Takahashi, Daisuke" uniqKey="Takahashi D" first="Daisuke" last="Takahashi">Daisuke Takahashi</name></author><author><name sortKey="Urashima, Mitsuyoshi" sort="Urashima, Mitsuyoshi" uniqKey="Urashima M" first="Mitsuyoshi" last="Urashima">Mitsuyoshi Urashima</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Cohort Studies</term><term>Cross-Sectional Studies</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Parkinson Disease (blood)</term><term>Parkinson Disease (genetics)</term><term>Polymorphism, Genetic</term><term>Receptors, Calcitriol (genetics)</term><term>Severity of Illness Index</term><term>Vitamin D (analogs & derivatives)</term><term>Vitamin D (blood)</term><term>Vitamin D (genetics)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analogs & derivatives" xml:lang="en"><term>Vitamin D</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Vitamin D</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Receptors, Calcitriol</term><term>Vitamin D</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Aged, 80 and over</term><term>Cohort Studies</term><term>Cross-Sectional Studies</term><term>Female</term><term>Genetic Predisposition to Disease</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Polymorphism, Genetic</term><term>Severity of Illness Index</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">We aimed to examine associations among serum 25-hydroxyvitamin D levels, 1,25-dihyroxyvitamin D levels, vitamin D receptor polymorphisms, vitamin D binding protein gene polymorphisms, and the severity of Parkinson's disease. In 137 patients, the severity of Parkinson's disease was evaluated using Hoehn & Yahr stage and Unified Parkinson's Disease Rating Stage by neurologists and compared with 25-hydroxyvitamin D, 1,25-hydroxyvitamin D, vitamin D receptor polymorphisms, ie, FokI (rs10735810), BsmI (rs1544410), Cdx2 (rs11568820), ApaI (rs7976091), and TaqI (rs731236), and vitamin D binding protein gene polymorphisms GC1 (rs7041)/GC2 (rs4588) in a cross-sectional study. Mean ± standard deviation levels of 25-hydroxyvitamin D were 21.1 ± 9.0 ng/mL. Levels were deficient (<20 ng/mL) in 49% of patients. In contrast, 1,25-hydroxyvitamin D levels were considered normal in all patients. Higher circulating 25-hydroxyvitamin D levels were significantly associated with milder Parkinson's disease evaluated by Hoehn & Yahr stage (P = .002) and total Unified Parkinson's Disease Rating Stage (P = .004) even after multivariate adjustment for 8 covariates, including disease duration. However, significant associations were not observed in 1,25-hydroxyvitamin D levels. Under multivariate analysis with 25-hydroxyvitamin D as well as other 8 covariates including disease duration, carriers of vitamin D receptor FokICC genotype had a milder form of Parkinson's disease: odds ratio, 0.32; 95% confidence interval, 0.16 to 0.66, P = 0.002. These results suggest that higher 25-hydroxyvitamin D levels and the vitamin D receptor FokICC genotype may be independently associated with milder forms of Parkinson's disease. However, significant associations were not observed in 1,25-hydroxyvitamin D levels.</div></front></TEI><affiliations><list><country><li>Japon</li></country><settlement><li>Tokyo</li></settlement></list><tree><noCountry><name sortKey="Hashimoto, Masaya" sort="Hashimoto, Masaya" uniqKey="Hashimoto M" first="Masaya" last="Hashimoto">Masaya Hashimoto</name><name sortKey="Kawasaki, Keiichi" sort="Kawasaki, Keiichi" uniqKey="Kawasaki K" first="Keiichi" last="Kawasaki">Keiichi Kawasaki</name><name sortKey="Murakami, Maiko" sort="Murakami, Maiko" uniqKey="Murakami M" first="Maiko" last="Murakami">Maiko Murakami</name><name sortKey="Noya, Miki" sort="Noya, Miki" uniqKey="Noya M" first="Miki" last="Noya">Miki Noya</name><name sortKey="Takahashi, Daisuke" sort="Takahashi, Daisuke" uniqKey="Takahashi D" first="Daisuke" last="Takahashi">Daisuke Takahashi</name><name sortKey="Urashima, Mitsuyoshi" sort="Urashima, Mitsuyoshi" uniqKey="Urashima M" first="Mitsuyoshi" last="Urashima">Mitsuyoshi Urashima</name><name sortKey="Yoshioka, Masayuki" sort="Yoshioka, Masayuki" uniqKey="Yoshioka M" first="Masayuki" last="Yoshioka">Masayuki Yoshioka</name></noCountry><country name="Japon"><noRegion><name sortKey="Suzuki, Masahiko" sort="Suzuki, Masahiko" uniqKey="Suzuki M" first="Masahiko" last="Suzuki">Masahiko Suzuki</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Santé/explor/MovDisordV3/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000F26 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000F26 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Santé
|area= MovDisordV3
|flux= Main
|étape= Exploration
|type= RBID
|clé= pubmed:22213340
|texte= 25-hydroxyvitamin D, vitamin D receptor gene polymorphisms, and severity of Parkinson's disease.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:22213340" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a MovDisordV3
| This area was generated with Dilib version V0.6.23. |  |